Typically, spherification is achieved through evenly dispersing sodium alginate into a flavoured liquid (commonly, the ratio will be 0.5g of sodium alginate to every 100g of liquid) and plunging into a bath of cold water mixed with calcium chloride (also 0.5g to 100g of water). Upon being dropped into the solution, the liquid disperses and each droplet begins to encapsulate in a bubble. Once the spheres are formed, they can be transferred to another pool of fresh water to wash off the solution before being served. The whole process should take no longer than one hour.
Some of the issues with spherification as it was originally conceived are that it will not work with ingredients of a high acidity (the PH needs to be above 3.6, though this can be reduced using sodium citrate the resulting flavour may be quite sour) or calcium content, and that the ingredient will continue to jellify once it is out of the bath - meaning that unless it is served quickly it will turn into a solid ball of flavoured jelly rather than an essence protected by an imperceptibly thin membrane.
Reverse spherification – the process of adding a calcium-based or calcium-enriched product to a bath of sodium alginate – solves these issues, allowing the use of alcohol or milk and cream-based ingredients, for example, while also creating more durable, longer-lasting spheres. But reverse spherification has some downfalls of its own; notably that the liquid may need to be thickened with xanthan gum to allow it to penetrate the dense sodium alginate solution, and that the bath will take longer to prepare and requires the use of distilled water.
Unlike many other modernist techniques, the equipment needed for spherification is actually quite rudimentary; a syringe or spoon for transferring the liquid, a container to hold the water solution, precisions scales and a blender (immersion if possible) are all that are strictly necessary. But if you are serious about spherification, it is probably wise to invest in some of the other gadgets available, such as a caviar maker (for evenly distributing the droplets of liquid into the water solution), vacuum chamber (to eliminate air bubbles created by mixing sodium alginate with a liquid), measuring spoons, moulds and PH indicator paper.